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Antibacterial Polyketide Heterodimers from Pyrenacantha kaurabassana Tubers

Author:
Boudesocque-Delaye, Leslie, Agostinho, Daniel, Bodet, Charles, Thery-Kone, Isabelle, Allouchi, Hassan, Gueiffier, Alain, Nuzillard, Jean-Marc, Enguehard-Gueiffier, Cécile
Source:
Journal of natural products 2015 v.78 no.4 pp. 597-603
ISSN:
1520-6025
Subject:
Helicobacter pylori, Staphylococcus aureus, antibacterial properties, emodin, nuclear magnetic resonance spectroscopy, polyketides, tubers
Abstract:
Two heterodimers comprising anthraquinone and methylbenzoisocoumarin moieties (1 and 2) were isolated, together with emodin and physcion from the tubers of Pyrenacantha kaurabassana. The structures of 1 and 2 were established by NMR spectroscopy, including the analysis of a 2D INADEQUATE spectrum. On the basis of the data obtained, the structures that were previously proposed in the literature for these compounds were revised. Compounds 1 and 2 showed antibacterial activity against three different strains of Staphylococcus aureus. Compound 2 also showed bactericidal activity against Helicobacter pylori.
Agid:
5498134