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Eremophilane Sesquiterpenes and Diphenyl Thioethers from the Soil Fungus Penicillium copticola PSU-RSPG138

Author:
Daengrot, Charuwan, Rukachaisirikul, Vatcharin, Tansakul, Chittreeya, Thongpanchang, Tienthong, Phongpaichit, Souwalak, Bowornwiriyapan, Kawitsara, Sakayaroj, Jariya
Source:
Journal of natural products 2015 v.78 no.4 pp. 615-622
ISSN:
1520-6025
Subject:
Penicillium, Plasmodium falciparum, antimalarials, cytotoxicity, inhibitory concentration 50, sesquiterpenoids, soil fungi, spectroscopy
Abstract:
Four new compounds including two eremophilane sesquiterpenes, penicilleremophilanes A (1) and B (2), as well as two sulfur-containing biphenols, penicillithiophenols A (3) and B (4), were isolated from the soil fungus Penicillium copticola PSU-RSPG138 together with 16 known compounds. Their structures were elucidated by spectroscopic methods. Known sporogen AO-1 exhibited significant antimalarial activity against Plasmodium falciparum with an IC₅₀ value of 1.53 μM and cytotoxic activity to noncancerous (Vero) cell lines with an IC₅₀ value of 4.23 μM. Although compound 1 was approximately half as active against P. falciparum with the IC₅₀ value of 3.45 μM, it showed much weaker cytotoxic activity.
Agid:
5498136