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Bioactive Maleic Anhydrides and Related Diacids from the Aquatic Hyphomycete Tricladium castaneicola

Author:
Han, Chunguang, Furukawa, Hiroyuki, Tomura, Tomohiko, Fudou, Ryosuke, Kaida, Kenichi, Choi, Bong-Keun, Imokawa, Genji, Ojika, Makoto
Source:
Journal of natural products 2015 v.78 no.4 pp. 639-644
ISSN:
1520-6025
Subject:
Hyphomycetes, Phytophthora, cytotoxicity, fungi, hydrophobicity, maleic anhydrides, melanoma, metabolites, spectral analysis, succinic acid
Abstract:
Four maleic anhydride derivatives, tricladolides A–D (1–4), and three alkylidene succinic acid derivatives, tricladic acids A–C (5–7), were isolated from the aquatic hyphomycete Tricladium castaneicola. The structures of these compounds were determined by spectroscopic analysis, and all were found to be novel. The compounds exhibited inhibitory activity against fungi, particularly Phytophthora sp., a plant pathogen of oomycetes. The inhibitory activity of these metabolites revealed the importance of the cyclic anhydride structure and the lipophilicity of the alkyl side chain. On the other hand, the cytotoxicity of the compounds against B16 melanoma cells indicated that the cyclic anhydride structure was not essential.
Agid:
5498140