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Bioactive Metabolites from the Fruits of Psoralea corylifolia

Author:
Won, Tae Hyung, Song, Inn-Hye, Kim, Kuk-Hwa, Yang, Woo-Young, Lee, Sang Kook, Oh, Dong-Chan, Oh, Won-Keun, Oh, Ki-Bong, Shin, Jongheon
Source:
Journal of natural products 2015 v.78 no.4 pp. 666-673
ISSN:
1520-6025
Subject:
Cullen corylifolium, Staphylococcus, chemical analysis, circular dichroism spectroscopy, dried fruit, flavonoids, fruits, metabolites
Abstract:
Twenty-four metabolites, including seven new compounds (1–7), were isolated from the dried fruits of Psoralea corylifolia. On the basis of combined spectroscopic and chemical analysis, the new compounds were determined to be six flavonoids (1–6) and a meroterpenoid (7). The absolute configurations of the natural products obtained, including the previously undetermined 16 and 17, were assigned by several methods, such as NOE spectroscopy, optical rotation, and CD spectroscopy. Several of these compounds exhibited moderate inhibitory activity toward Staphylococcus mutans-derived SrtA (2, 6, and 16) and significant stimulation of SIRT1 activity (2, 3, and 15).
Agid:
5498146