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Bacillusin A, an Antibacterial Macrodiolide from Bacillus amyloliquefaciens AP183

Author:
Ravu, Ranga Rao, Jacob, Melissa R., Chen, Xiaolong, Wang, Mei, Nasrin, Shamima, Kloepper, Joseph W., Liles, Mark R., Mead, David A., Khan, Ikhlas A., Li, Xing-Cong
Source:
Journal of natural products 2015 v.78 no.4 pp. 924-928
ISSN:
1520-6025
Subject:
Bacillus amyloliquefaciens, Enterococcus faecium, antibacterial properties, antibiotic resistance, fractionation, lactones, methicillin, methicillin-resistant Staphylococcus aureus, minimum inhibitory concentration, nuclear magnetic resonance spectroscopy, polyketides, spectral analysis
Abstract:
Bioassay-guided fractionation of the organic extracts of a Bacillus amyloliquefaciens strain (AP183) led to the discovery of a new macrocyclic polyene antibiotic, bacillusin A (1). Its structure was assigned by interpretation of NMR and MS spectroscopic data as a novel macrodiolide composed of dimeric 4-hydroxy-2-methoxy-6-alkenylbenzoic acid lactones with conjugated pentaene-hexahydroxy polyketide chains. Compound 1 showed potent antibacterial activities against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium with minimum inhibitory concentrations in a range of 0.6 to 1.2 μg/mL. The biosynthetic significance of this unique class of antibiotic compounds is briefly discussed.
Agid:
5498157