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Striatoids A–F, Cyathane Diterpenoids with Neurotrophic Activity from Cultures of the Fungus Cyathus striatus

Author:
Bai, Rui, Zhang, Cheng-Chen, Yin, Xia, Wei, Jing, Gao, Jin-Ming
Source:
Journal of natural products 2015 v.78 no.4 pp. 783-788
ISSN:
1520-6025
Subject:
Cyathus, diterpenoids, fungi, nerve growth factor, neurites, nuclear magnetic resonance spectroscopy, rats, spectral analysis
Abstract:
Six new highly oxygenated polycyclic cyathane-xylosides, named striatoids A–F (1–6), were isolated from the cultures of the basidiomycete Cyathus striatus. Their structures were established by comprehensive spectroscopic analysis including 2D NMR (HMBC, HSQC, ROESY, ¹H–¹H–COSY) and HRESIMS experiments. Compounds 2 and 3 possess an unusual 15,4′-ether ring system. The isolated compounds dose-dependently enhanced nerve growth factor (NGF)-mediated neurite outgrowth in rat pheochromocytoma (PC-12) cells.
Agid:
5498166