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17-Norpimaranes and (9βH)-17-Norpimaranes from the Tuber of Icacina trichantha

Author:
Zhao, Ming, Onakpa, Michael Monday, Chen, Wei-Lun, Santarsiero, Bernard D., Swanson, Steven M., Burdette, Joanna E., Asuzu, Isaac Uzoma, Che, Chun-Tao
Source:
Journal of natural products 2015 v.78 no.4 pp. 789-796
ISSN:
1520-6025
Subject:
Icacina, X-ray diffraction, anticarcinogenic activity, breast neoplasms, cytotoxicity, diterpenoids, humans, melanoma, ovarian neoplasms, spectroscopy, tubers
Abstract:
Seven new 17-norpimarane and (9βH)-17-norpimarane diterpenoids, icacinlactones A–G (1–7), were isolated from the tuber of Icacina trichantha. The structures were elucidated by spectroscopic and HRMS techniques, and the absolute configuration of 2 was determined by means of X-ray crystallographic analysis. Compounds 1–7, as well as four known related structures, were evaluated for cytotoxic activity against MDA-MB-435 (human melanoma cancer), MDA-MB-231 (human breast cancer), and OVCAR3 (human ovarian cancer) cell lines. Several of these natural products displayed significant cytotoxic activity, with humirianthenolide C being the most active.
Agid:
5498167