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Limonoids with 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitory Activities from Dysoxylum mollissimum

Author:
Zhou, Bin, Shen, Yu, Wu, Yan, Leng, Ying, Yue, Jian-Min
Source:
Journal of natural products 2015 v.78 no.8 pp. 2116-2122
ISSN:
1520-6025
Subject:
Dysoxylum, branches, chemical structure, humans, inhibitory concentration 50, limonoids, mice, spectral analysis
Abstract:
Thirteen new limonoids, dysoxylumosins A–M (1–13), along with six known analogues (14–19) were isolated from the twigs of Dysoxylum mollissimum. Their structures were established on the basis of spectroscopic data analysis. Compounds 1–6, 8, and 12 exhibited significant inhibitory activities against human and/or mouse 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). Dysoxylumosin F (6), the most potent substance isolated, showed an IC₅₀ value of 9.6 ± 0.90 nM against human 11β-HSD1.
Agid:
5498320