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Phenolic Compounds from the Leaves and Twigs of Osteomeles schwerinae That Inhibit Rat Lens Aldose Reductase and Vessel Dilation in Zebrafish Larvae

Author:
Lee, Ik-Soo, Jung, Seung-Hyun, Lee, Yun Mi, Choi, So-Jin, Sun, Hang, Kim, Jin Sook
Source:
Journal of natural products 2015 v.78 no.9 pp. 2249-2254
ISSN:
1520-6025
Subject:
Danio rerio, Osteomeles, aldehyde reductase, branches, chemical structure, enzyme inhibition, eye lens, glucose, glycosides, inhibitory concentration 50, larvae, leaves, lignans, rats, spectral analysis
Abstract:
Three new phenolic biphenyl derivatives (1–3) and one new lignan glycoside (4) were isolated from the leaves and twigs of Osteomeles schwerinae. The structures of the new compounds were established by spectroscopic data interpretation. The inhibitory effects of 1–4 on rat lens aldose reductase in vitro were examined, and compounds 1–3 markedly inhibited the enzyme with IC₅₀ values of 3.8 to 13.8 μM. In addition, the effects of these isolates on the dilation of hyaloid-retinal vessels induced by high glucose (HG) in zebrafish larvae were investigated. Compound 1 was the most effective in reducing HG-induced dilation of hyaloid-retinal vessels.
Agid:
5498336