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Cassane Diterpenoids from the Pericarps of Caesalpinia bonduc
- Zhang, Panpan, Tang, Chunping, Yao, Sheng, Ke, Changqiang, Lin, Ge, Hua, Hui-Ming, Ye, Yang
- Journal of natural products 2016 v.79 no.1 pp. 24-29
- Caesalpinia bonduc, chemical structure, diterpenoids, neuroprotective effect, nuclear magnetic resonance spectroscopy, pericarp, spectral analysis
- Ten new cassane-type diterpenoids, caesalbonducins D–F (1–3), 6-deacetoxybonducellpin B (4), 3-acetoxy-α-caesalpin (5), 2(3)-en-α-caesalpin (6), 1α-hydroxycaesalpinin J (7), 1α-hydroxy-6-decaetoxysalpinin J (8), 6α-hydroxycaesall M (9), and 6α-hydroxy-14(17)-dehydrocaesalpin F (10), along with eight known compounds (11–18), were isolated from the pericarps of Caesalpinia bonduc. Compounds 1–3 and 11 are methyl-migrated cassane-type diterpenoids with a 19(4→3)-cassane skeleton. The structures of 1–10 were elucidated on the basis of 1D and 2D NMR methods and other spectroscopic analysis. The neuroprotective effects of the isolated compounds were evaluated.