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Cassane Diterpenoids from the Pericarps of Caesalpinia bonduc

Author:
Zhang, Panpan, Tang, Chunping, Yao, Sheng, Ke, Changqiang, Lin, Ge, Hua, Hui-Ming, Ye, Yang
Source:
Journal of natural products 2016 v.79 no.1 pp. 24-29
ISSN:
1520-6025
Subject:
Caesalpinia bonduc, chemical structure, diterpenoids, neuroprotective effect, nuclear magnetic resonance spectroscopy, pericarp, spectral analysis
Abstract:
Ten new cassane-type diterpenoids, caesalbonducins D–F (1–3), 6-deacetoxybonducellpin B (4), 3-acetoxy-α-caesalpin (5), 2(3)-en-α-caesalpin (6), 1α-hydroxycaesalpinin J (7), 1α-hydroxy-6-decaetoxysalpinin J (8), 6α-hydroxycaesall M (9), and 6α-hydroxy-14(17)-dehydrocaesalpin F (10), along with eight known compounds (11–18), were isolated from the pericarps of Caesalpinia bonduc. Compounds 1–3 and 11 are methyl-migrated cassane-type diterpenoids with a 19(4→3)-cassane skeleton. The structures of 1–10 were elucidated on the basis of 1D and 2D NMR methods and other spectroscopic analysis. The neuroprotective effects of the isolated compounds were evaluated.
Agid:
5498348