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Identification and Evaluation of Antiepileptic Activity of C21 Steroidal Glycosides from the Roots of Cynanchum wilfordii

Author:
Li, Jin-Long, Gao, Zhao-Bing, Zhao, Wei-Min
Source:
Journal of natural products 2016 v.79 no.1 pp. 89-97
ISSN:
1520-6025
Subject:
Cynanchum wilfordii, chemical structure, glycosides, mice, models, roots, spectral analysis
Abstract:
Nine new C₂₁ steroidal glycosides, named cynawilfosides A–I (1–9), along with 12 known compounds were isolated from the roots of Cynanchum wilfordii. The structures of the new compounds were elucidated by spectroscopic analysis and chemical methods. The five major components, cynawilfoside A (1), cynauricoside A (11), wilfoside C1N (16), wilfoside K1N (17), and cyanoauriculoside G (18), exhibited significant protection activity in a maximal electroshock (MES)-induced mouse seizure model with ED₅₀ values of 48.5, 95.3, 124.1, 72.3, and 88.1 mg/kg, respectively.
Agid:
5498358