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Aspidofractinine and Eburnane Alkaloids from a North Borneo Kopsia. Ring-Contracted, Additional Ring-Fused, and Paucidactine-Type Aspidofractinine Alkaloids from K. pauciflora

Author:
Yap, Wai-Sum, Gan, Chew-Yan, Sim, Kae-Shin, Lim, Siew-Huah, Low, Yun-Yee, Kam, Toh-Seok
Source:
Journal of natural products 2016 v.79 no.1 pp. 230-239
ISSN:
1520-6025
Subject:
X-ray diffraction, humans, indole alkaloids, Borneo
Abstract:
Eleven new indole alkaloids (1–11) comprising seven aspidofractinine and four eburnane alkaloids, were isolated from the stem-bark extract of Kopsia pauciflora occurring in Malaysian Borneo. The aspidofractinine alkaloids include a ring-contracted, an additional ring-fused, a paucidactine regioisomer, two paucidactine, and one kopsine alkaloid. The structures of several of these alkaloids were also confirmed by X-ray diffraction analyses. The bisindole alkaloids isolated, norpleiomutine and kopsoffinol, showed in vitro growth inhibitory activity against human PC-3, HCT-116, MCF-7, and A549 cells and moderate effects in reversing multidrug-resistance in vincristine-resistant human KB cells.
Agid:
5498377