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Anti-hepatitis C Virus Natural Product from a Fungus, Penicillium herquei

Author:
Nishikori, Shu, Takemoto, Kenji, Kamisuki, Shinji, Nakajima, Syo, Kuramochi, Kouji, Tsukuda, Senko, Iwamoto, Masashi, Katayama, Yuri, Suzuki, Takahiro, Kobayashi, Susumu, Watashi, Koichi, Sugawara, Fumio
Source:
Journal of natural products 2016 v.79 no.2 pp. 442-446
ISSN:
1520-6025
Subject:
Penicillium, culture media, fungi, inhibitory concentration 50, microbial culture, nuclear magnetic resonance spectroscopy, octane, spectral analysis, viruses
Abstract:
New diazabicyclo[2.2.2]octane derivatives, peniciherquamides A–C (1–3), and a novel herqueinone derivative, neoherqueinone (5), were isolated from a fungal culture broth of Penicillium herquei. The structures of these novel compounds were determined by interpretation of spectroscopic data (1D/2D NMR, MS, and IR). Four known compounds, preparaherquamide (4), peniciherqueinone (6), and herqueinone/isoherqueinone (7/7a), were also obtained. The isolated compounds were tested for anti-hepatitis C virus (HCV) activity, and peniciherquamide C (3) was found to display an IC₅₀ value of 5.1 μM. To our knowledge, this is the first report of a diazabicyclo[2.2.2]octane derivative with anti-HCV activity.
Agid:
5498381