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Carolignans from the Aerial Parts of Euphorbia sikkimensis and Their Anti-HIV Activity

Author:
Jiang, Cheng, Luo, Pan, Zhao, Yu, Hong, Jialing, Morris-Natschke, Susan L., Xu, Jun, Chen, Chin-Ho, Lee, Kuo-Hsiung, Gu, Qiong
Source:
Journal of natural products 2016 v.79 no.3 pp. 578-583
ISSN:
1520-6025
Subject:
Euphorbia, aerial parts, antiretroviral properties, circular dichroism spectroscopy, enantiomers, lignans, median effective concentration, polyphenols, spectral analysis
Abstract:
Seven new carolignans, including two pairs of enantiomers (±)-erythro-7′-methylcarolignan E (1a/1b) and (±)-threo-7′-methylcarolignan E (2a/2b), (+)-threo-carolignan E (3a), (+)-erythro-carolignan E (4a), and (−)-erythro-carolignan Z (5), together with four known lignans (3b, 4b, 6, and 7) and six polyphenols (8–13) were isolated from the aerial parts of Euphorbia sikkimensis. The structures of the new compounds were elucidated by spectroscopic analysis, and their absolute configurations were determined by electronic circular dichroism calculations. Seven of the isolates were examined for anti-HIV effects, and compounds 1a and 1b showed moderate anti-HIV activity with EC₅₀ values of 6.3 and 5.3 μM.
Agid:
5498421