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Bafilomycins and Odoriferous Sesquiterpenoids from Streptomyces albolongus Isolated from Elephas maximus Feces

Ding, Nan, Jiang, Yi, Han, Li, Chen, Xiu, Ma, Jian, Qu, Xiaodan, Mu, Yu, Liu, Jiang, Li, Liya, Jiang, Chenglin, Huang, Xueshi
Journal of natural products 2016 v.79 no.4 pp. 799-805
Candida parapsilosis, Elephas maximus, Streptomyces albolongus, antifungal properties, bacteria, culture media, cytotoxicity, feces, fungi, humans, inhibitory concentration 50, minimum inhibitory concentration, neoplasms, sesquiterpenoids, spectral analysis
From a fermentation broth of Streptomyces albolongus obtained from Elephas maximus feces, nine bafilomycins (1–9) and seven odoriferous sesquiterpenoids (10–16) were isolated. The structures of the new compounds, including three bafilomycins, 19-methoxybafilomycin C1 amide (1), 21-deoxybafilomycin A1 (2), and 21-deoxybafilomycin A2 (3), and two sesquiterpenoid degradation products, (1β,4β,4aβ,8aα)-4,8a-dimethyloctahydronaphthalene-1,4a(2H)-diol (10) and (1β,4β,4aβ,7α,8aα)-4,8a-dimethyloctahydronaphthalene-1,4a,7(2H)-triol (11), were elucidated by comprehensive spectroscopic data analysis. The cytotoxicity activity against four human cancer cell lines and antimicrobial activities against a panel of bacteria and fungi of all compounds isolated were evaluated. Compounds 1, 7, and 8 were cytotoxic, with IC₅₀ values ranging from 0.54 to 5.02 μM. Compounds 2, 7, 8, and 10 showed strong antifungal activity against Candida parapsilosis, with MIC values of 3.13, 1.56, 1.56, and 3.13 μg/mL respectively.