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Bafilomycins and Odoriferous Sesquiterpenoids from Streptomyces albolongus Isolated from Elephas maximus Feces

Author:
Ding, Nan, Jiang, Yi, Han, Li, Chen, Xiu, Ma, Jian, Qu, Xiaodan, Mu, Yu, Liu, Jiang, Li, Liya, Jiang, Chenglin, Huang, Xueshi
Source:
Journal of natural products 2016 v.79 no.4 pp. 799-805
ISSN:
1520-6025
Subject:
Candida parapsilosis, Elephas maximus, Streptomyces albolongus, antifungal properties, bacteria, culture media, cytotoxicity, feces, fungi, humans, inhibitory concentration 50, minimum inhibitory concentration, neoplasms, sesquiterpenoids, spectral analysis
Abstract:
From a fermentation broth of Streptomyces albolongus obtained from Elephas maximus feces, nine bafilomycins (1–9) and seven odoriferous sesquiterpenoids (10–16) were isolated. The structures of the new compounds, including three bafilomycins, 19-methoxybafilomycin C1 amide (1), 21-deoxybafilomycin A1 (2), and 21-deoxybafilomycin A2 (3), and two sesquiterpenoid degradation products, (1β,4β,4aβ,8aα)-4,8a-dimethyloctahydronaphthalene-1,4a(2H)-diol (10) and (1β,4β,4aβ,7α,8aα)-4,8a-dimethyloctahydronaphthalene-1,4a,7(2H)-triol (11), were elucidated by comprehensive spectroscopic data analysis. The cytotoxicity activity against four human cancer cell lines and antimicrobial activities against a panel of bacteria and fungi of all compounds isolated were evaluated. Compounds 1, 7, and 8 were cytotoxic, with IC₅₀ values ranging from 0.54 to 5.02 μM. Compounds 2, 7, 8, and 10 showed strong antifungal activity against Candida parapsilosis, with MIC values of 3.13, 1.56, 1.56, and 3.13 μg/mL respectively.
Agid:
5498440