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7,7-Dimethylaporphine and Other Alkaloids from the Bark of Guatteria friesiana

Author:
Costa, Emmanoel V., Pinheiro, Maria Lúcia B., Maia, Beatriz Helena L. N. S., Marques, Francisco A., Ruiz, Ana Lúcia T. G., Marchetti, Gabriela M., Carvalho, João Ernesto de, Soares, Milena B. P., Costa, Cinara O. S., Galvão, Alexandre F. C., Lopes, Norberto P., Koolen, Hector H. F., Bezerra, Daniel P., Barison, Andersson
Source:
Journal of natural products 2016 v.79 no.6 pp. 1524-1531
ISSN:
1520-6025
Subject:
Guatteria, alkaloids, bark, cytotoxicity, neoplasm cells, spectral analysis
Abstract:
Phytochemical investigation of the bark of Guatteria friesiana afforded 12 new aporphines (1–12), along with nine known alkaloids (13–21). The structures of the new alkaloids were determined on the basis of spectroscopic data interpretation. The cytotoxic activity of the isolated compounds against a small panel of tumor cell lines was assessed using the Alamar blue assay.
Agid:
5498540