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Deuterium-Labeled Precursor Feeding Reveals a New pABA-Containing Meroterpenoid from the Mango Pathogen Xanthomonas citri pv. mangiferaeindicae
- Saleh, Hesham, Petras, Daniel, Mainz, Andi, Kerwat, Dennis, Nalbantsoy, Ayse, Erzurumlu, Yalcin, Süssmuth, Roderich D.
- Journal of natural products 2016 v.79 no.6 pp. 1532-1537
- autophagy, cytotoxicity, humans, mangoes, neoplasms, pathogens, stable isotopes
- A new para-aminobenzoic-acid-containing natural product from the mango pathogenic organism Xanthomonas citri pv. mangiferaeindicae is described. By means of stable isotope precursor feeding combined with nontargeted LC-MS/MS, the generated spectra were clustered and visualized in a molecular network. This led to the identification of a new member of the meroterpenoids, termed xanthomonic acid, which is composed of an isoprenylated para-aminobenzoic acid. In vitro cytotoxicity assays demonstrated activity of xanthomonic acid against several human cancer cell lines by induction of autophagy.