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Isolation and Structure of Cancer Cell Growth Inhibitory Tetracyclic Triterpenoids from the Zimbabwean Monadenium lugardae

Author:
Pettit, George R., Ye, Qinghua, Herald, Delbert L., Knight, John C., Hogan, Fiona, Melody, Noeleen, Mukku, Venugopal J. R. V., Doubek, Dennis L., Chapuis, Jean-Charles
Source:
Journal of natural products 2016 v.79 no.6 pp. 1598-1603
ISSN:
1520-6025
Subject:
cell growth, humans, mass spectrometry, medicinal plants, neoplasm cells, neoplasms, nuclear magnetic resonance spectroscopy, triterpenoids
Abstract:
The Zimbabwean medicinal plant Monadenium lugardae was evaluated as a potential source of new anticancer constituents. Four new tetracyclic triterpene (1–4) were isolated, accompanied by four previously known triterpenes (5–8). Against a panel of human tumor cell lines, lugardstatins 1 (1) and 2 (2) had good cancer cell growth inhibitory activity. All of the triterpene structures (1–8) were established by 1D and 2D NMR spectrometric and HR mass spectrometric analysis.
Agid:
5498547