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Pyristriatins A and B: Pyridino-Cyathane Antibiotics from the Basidiomycete Cyathus cf. striatus

Author:
Richter, Christian, Helaly, Soleiman E., Thongbai, Benjarong, Hyde, Kevin D., Stadler, Marc
Source:
Journal of natural products 2016 v.79 no.6 pp. 1684-1688
ISSN:
1520-6025
Subject:
Cyathus, Gram-positive bacteria, antibiotics, antimicrobial properties, cytotoxicity, diterpenoids, fungi, nuclear magnetic resonance spectroscopy, pyridines, Thailand
Abstract:
Two novel pyridino-cyathane diterpenoids, pyristriatins A and B (1 and 2), together with striatin C (3) were isolated from cultures of Cyathus cf. striatus, a basidiomycete that was found during a field trip in northern Thailand. The pyristriatins showed antimicrobial effects against Gram-positive bacteria and fungi. The isolation, structure elucidation, relative configuration, and biological and cytotoxic activity are described. Their structures were assigned by HRMS and NMR spectroscopy. We also describe the first 2D NMR assignment of striatin C. Pyristriatins A and B are the first cyathane natural products featuring a pyridine ring.
Agid:
5498551