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Pepluane and Paraliane Diterpenoids from Euphorbia peplus with Potential Anti-inflammatory Activity

Author:
Wan, Luo-Sheng, Chu, Rui, Peng, Xing-Rong, Zhu, Guo-Lei, Yu, Mu-Yuan, Li, Lei, Zhou, Lin, Lu, Shuang-Yang, Dong, Jin-Run, Zhang, Zhi-Run, Li, Yan, Qiu, Ming-Hua
Source:
Journal of natural products 2016 v.79 no.6 pp. 1628-1634
ISSN:
1520-6025
Subject:
Euphorbia peplus, acetone, anti-inflammatory activity, diterpenoids, inhibitory concentration 50, macrophages, mice, models, nitric oxide, nuclear magnetic resonance spectroscopy, spectral analysis
Abstract:
Twelve new diterpenoids based on two rare skeletal types, namely, paralianones A–D (1–4) and pepluanols A–H (5–12), along with five known compounds, were isolated from an acetone extract of Euphorbia peplus. Their structures were proposed based on 1D and 2D NMR spectroscopic data analysis. These diterpenoids were evaluated for potential anti-inflammatory activity in a lipopolysaccharide-stimulated mouse macrophage cellular model. Compounds 3, 4, 11, 13, and 16 displayed moderate inhibitory effects on NO inhibition, with IC₅₀ values ranging from 29.9 to 38.3 μM.
Agid:
5498552