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Lanostane Triterpenes Isolated from Antrodia heteromorpha and Their Inhibitory Effects on RANKL-Induced Osteoclastogenesis

Author:
Kwon, Jaeyoung, Lee, Hyaemin, Yoon, Yeo Dae, Hwang, Bang Yeon, Guo, Yuanqiang, Kang, Jong Soon, Kim, Jae-Jin, Lee, Dongho
Source:
Journal of natural products 2016 v.79 no.6 pp. 1689-1693
ISSN:
1520-6025
Subject:
Antrodia, chemical structure, culture media, nuclear magnetic resonance spectroscopy, transcription factor NF-kappa B, triterpenoids
Abstract:
Two new spiro-lanostane triterpenoids, antrolactones A and B (1 and 2), along with polyporenic acid C (3), were isolated from an EtOAc-soluble extract of Antrodia heteromorpha culture medium, and the chemical structures of the new compounds were elucidated by application of NMR, MS, and ECD spectroscopic techniques. All isolated compounds exhibited inhibitory effects on receptor activator of nuclear factor-kappaB ligand-induced osteoclastogenesis.
Agid:
5498553