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Lanostane Triterpenes Isolated from Antrodia heteromorpha and Their Inhibitory Effects on RANKL-Induced Osteoclastogenesis
- Kwon, Jaeyoung, Lee, Hyaemin, Yoon, Yeo Dae, Hwang, Bang Yeon, Guo, Yuanqiang, Kang, Jong Soon, Kim, Jae-Jin, Lee, Dongho
- Journal of natural products 2016 v.79 no.6 pp. 1689-1693
- Antrodia, chemical structure, culture media, nuclear magnetic resonance spectroscopy, transcription factor NF-kappa B, triterpenoids
- Two new spiro-lanostane triterpenoids, antrolactones A and B (1 and 2), along with polyporenic acid C (3), were isolated from an EtOAc-soluble extract of Antrodia heteromorpha culture medium, and the chemical structures of the new compounds were elucidated by application of NMR, MS, and ECD spectroscopic techniques. All isolated compounds exhibited inhibitory effects on receptor activator of nuclear factor-kappaB ligand-induced osteoclastogenesis.