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In Vitro Antibacterial Activity of Curcumin–Polymyxin B Combinations against Multidrug-Resistant Bacteria Associated with Traumatic Wound Infections
- Betts, Jonathan W., Sharili, Amir S., La Ragione, Roberto
M., Wareham, David W.
- Journal of natural products 2016 v.79 no.6 pp. 1702-1706
- antibacterial properties, bacteria, bacterial infections, curcumin, cytotoxicity, keratinocytes, minimum inhibitory concentration, multiple drug resistance, polymyxin B
- Bacterial infections resulting from nonsurgical traumatic wounds can be life threatening, especially those caused by multidrug-resistant (MDR) bacteria with limited therapeutic options. The antimicrobial activity of polymyxin B (1) and curcumin (2) alone and in combination was determined versus MDR bacterial isolates associated with traumatic wound infections. Cytotoxicity assays for 1 and 2 were undertaken in keratinocyte cell lines. Minimum inhibitory concentrations of 1 were significantly reduced in the presence of 2 (3- to 10-fold reduction), with synergy observed. Time–kill assays showed the combinations produced bactericidal activity. Cytotoxicity assays indicate the toxicity of 2 was reduced in the presence of 1.