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Convergent Formal Synthesis of (±)-Roseophilin
- Song, Chuanjun, Liu, Hui, Hong, Meiling, Liu, Yuanyuan, Jia, Feifei, Sun, Li, Pan, Zhenliang, Chang, Junbiao
- Journal of organic chemistry 2012 v.77 no.1 pp. 704-706
- cyclization reactions, moieties, organic chemistry, organic compounds
- A facile convergent synthesis of the tricyclic core 2 of roseophilin is described, which represents the shortest route so far for the formal synthesis of roseophilin. The key step was a tandem pyrrole acylation-Nazarov cyclization reaction to form the cyclopenta[b]pyrrole moiety 4.