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Bromophycoic Acids: Bioactive Natural Products from a Fijian Red Alga Callophycus sp.

Author:
Teasdale, Margaret E., Shearer, Tonya L., Engel, Sebastian, Alexander, Troy S., Fairchild, Craig R., Prudhomme, Jacques, Torres, Manuel, Le Roch, Karine, Aalbersberg, William, Hay, Mark E., Kubanek, Julia
Source:
Journal of organic chemistry 2012 v.77 no.18 pp. 8000-8006
ISSN:
1520-6904
Subject:
Rhodophyta, acids, biosynthesis, chemical reactions, chemical structure, fractionation, humans, methicillin-resistant Staphylococcus aureus, neoplasm cells, nuclear magnetic resonance spectroscopy, organic chemistry, organic compounds, parasites, pathogens, spectral analysis
Abstract:
Bioassay-guided fractionation of extracts from a Fijian red alga in the genus Callophycus resulted in the isolation of five new compounds of the diterpene-benzoate class. Bromophycoic acids A–E (1–5) were characterized by NMR and mass spectroscopic analyses and represent two novel carbon skeletons, one with an unusual proposed biosynthesis. These compounds display a range of activities against human tumor cell lines, malarial parasites, and bacterial pathogens including low micromolar suppression of MRSA and VREF.
Agid:
5499102