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CuCl/DABCO/4-HO-TEMPO-Catalyzed Aerobic Oxidative Synthesis of 2-Substituted Quinazolines and 4H-3,1-Benzoxazines

Author:
Han, Bing, Yang, Xiu-Long, Wang, Chao, Bai, Yong-Wei, Pan, Tai-Chao, Chen, Xin, Yu, Wei
Source:
Journal of organic chemistry 2012 v.77 no.2 pp. 1136-1142
ISSN:
1520-6904
Subject:
alcohols, aldehydes, catalysts, chemical reactions, chemical structure, organic chemistry, oxidants, oxygen
Abstract:
The Cu/N-ligand/TEMPO catalytic system was first applied to the aerobic oxidative synthesis of heterocycles. As demonstrated, 2-substituted quinazolines and 4H-3,1-benzoxazines were synthesized efficiently from the one-pot reaction of aldehydes with 2-aminobenzylamines and 2-aminobenzyl alcohols, respectively, by employing CuCl/DABCO/4-HO-TEMPO as the catalysts and oxygen as the terminal oxidant.
Agid:
5499200