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Microwave-Assisted Cobinamide Synthesis
Proinsias, Keith, Karczewski, Maksymilian, Zieleniewska, Anna, Gryko, Dorota
- Journal of organic chemistry 2014 v.79 no.16 pp. 7752-7757
- methodology, microwave treatment, organic chemistry, vitamin B12
- We present a new method for the preparation of cobinamide (CN)₂Cbi, a vitamin B₁₂ precursor, that should allow its broader utility. Treatment of vitamin B₁₂ with only NaCN and heating in a microwave reactor affords (CN)₂Cbi as the sole product. The purification procedure was greatly simplified, allowing for easy isolation of the product in 94% yield. The use of microwave heating proved beneficial also for (CN)₂Cbi(c-lactone) synthesis. Treatment of (CN)₂Cbi with triethanolamine led to (CN)₂Cbi(c-lactam).