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Transition Metal-Mediated CO and CC Bond-Forming Reactions: A Regioselective Strategy for the Synthesis of Imidazo[1,2-a]pyridines and Imidazo[1,2-a]pyrazines

Author:
Cao, Hua, Liu, Xiaohang, Liao, Jinqiang, Huang, Jianping, Qiu, Huifang, Chen, Qinlin, Chen, Yaoyi
Source:
Journal of organic chemistry 2014 v.79 no.22 pp. 11209-11214
ISSN:
1520-6904
Subject:
aldehydes, catalysts, chemical reactions, chemical structure, copper, ketones, organic chemistry, palladium, pyrazines, pyridines, regioselectivity
Abstract:
A novel and convenient transformation for the regiospecific synthesis of functionalized imidazo[1,2-a]pyridine aldehydes/ketones and 3-vinyl imidazo[1,2-a]pyridines has been developed via copper(I)- and palladium(II)-catalyzed cyclization. The one-pot reaction proceeds smoothly with commercially available catalysts and affords the products in moderate to good yields. It represents an efficient approach for the formation of C–N, CO, and CC bonds under mild conditions.
Agid:
5502976