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Copper-Catalyzed C–H Functionalization of Pyridines and Isoquinolines with Vinyl Azides: Synthesis of Imidazo Heterocycles

Author:
Donthiri, Ramachandra Reddy, Pappula, Venkatanarayana, Reddy, N. Naresh Kumar, Bairagi, Dipayan, Adimurthy, Subbarayappa
Source:
Journal of organic chemistry 2014 v.79 no.22 pp. 11277-11284
ISSN:
1520-6904
Subject:
aerobic conditions, azides, carbon-hydrogen bond activation, chemical reactions, isomers, isoquinolines, organic chemistry, pyridines
Abstract:
Copper(I) iodide-catalyzed oxidative C(sp²)–H functionalization of pyridines and isoquinolines for the synthesis of imidazo[1,2-a]pyridines and 2-phenylimidazo[2,1-a]isoquinolines with vinyl azides under mild aerobic conditions is reported. Good selectivity for 3-substituted pyridines and single isomer formation with isoquinolines were observed.
Agid:
5503024