PubAg

Main content area

Development of a Suzuki Cross-Coupling Reaction between 2-Azidoarylboronic Pinacolate Esters and Vinyl Triflates To Enable the Synthesis of [2,3]-Fused Indole Heterocycles

Author:
Jana, Navendu, Nguyen, Quyen, Driver, Tom G.
Source:
Journal of organic chemistry 2014 v.79 no.6 pp. 2781-2791
ISSN:
1520-6904
Subject:
Suzuki reaction, amination, chemical structure, esters, indoles, organic chemistry, regioselectivity
Abstract:
The scope and limitations of a Suzuki reaction between 2-azidoarylboronic acid pinacolate esters and vinyl triflates are reported. This cross-coupling reaction enables the regioselective synthesis of indoles after a subsequent Rhᴵᴵ₂-catalyzed sp²-C–H bond amination reaction.
Agid:
5503332