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Palladium-Catalyzed Carbonylation of o-Iodoanilines for Synthesis of Isatoic Anhydrides
- Gao, Sha, Chen, Ming, Zhao, Mi-Na, Du, Wei, Ren, Zhi-Hui, Wang, Yao-Yu, Guan, Zheng-Hui
- Journal of organic chemistry 2014 v.79 no.9 pp. 4196-4200
- anhydrides, catalytic activity, chemical reactions, chemical structure, organic chemistry, palladium
- A novel palladium-catalyzed oxidative double carbonylation of o-iodoanilines for the synthesis of isatoic anhydrides has been developed. The reaction employs readily available o-iodoanilines as the starting materials and proceeds under mild conditions. For extension, palladium-catalyzed oxidative carbonylation of anthranilic acids was developed for the synthesis of substituted isatoic anhydrides in high to excellent yields.