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Radical-Induced Metal and Solvent-Free Cross-Coupling Using TBAI–TBHP: Oxidative Amidation of Aldehydes and Alcohols with N-Chloramines via C–H Activation

Author:
Achar, Tapas Kumar, Mal, Prasenjit
Source:
Journal of organic chemistry 2015 v.80 no.1 pp. 666-672
ISSN:
1520-6904
Subject:
alcohols, aldehydes, ambient temperature, carbon-hydrogen bond activation, chemical structure, cross-coupling reactions, organic chemistry
Abstract:
A solvent-free cross-coupling method for oxidative amidation of aldehydes and alcohols via a metal-free radial pathway has been demonstrated. The proposed methodology uses the TBAI-TBHP combination which efficiently induces metal-free C–H activation of aldehydes under neat conditions at 50 °C or ball-milling conditions at room temperature.
Agid:
5503553