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Coproduct Promoted Povarov Reaction: Synthesis of Substituted Quinolines from Methyl Ketones, Arylamines, and α-Ketoesters

Author:
Gao, Qinghe, Liu, Shan, Wu, Xia, Zhang, Jingjing, Wu, Anxin
Source:
Journal of organic chemistry 2015 v.80 no.11 pp. 5984-5991
ISSN:
1520-6904
Subject:
chemistry, coproducts, quinolones
Abstract:
A highly efficient I₂-catalyzed Povarov-type reaction of methyl ketones, arylamines, and α-ketoesters is developed. This reaction utilizes a catalytic amount of HI coproduct as a promoter for the synthesis of substituted quinolones. This simple procedure represents an interesting new form of reactivity for the Povarov reaction with good functional group compatibility.
Agid:
5503686