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Regioselective Oxidative Trifluoromethylation of Imidazoheterocycles via C(sp2)–H Bond Functionalization

Author:
Monir, Kamarul, Bagdi, Avik Kumar, Ghosh, Monoranjan, Hajra, Alakananda
Source:
Journal of organic chemistry 2015 v.80 no.3 pp. 1332-1337
ISSN:
1520-6904
Subject:
air, ambient temperature, chemical bonding, chemical reactions, chemical structure, organic chemistry, pyridines, regioselectivity, thiazoles
Abstract:
Catalytic oxidative trifluoromethylation of imidazopyridines has been carried out at room temperature through the functionalization of the sp² C–H bond employing Langlois reagent under ambient air. A library of 3-(trifluoromethyl)imidazo[1,2-a]pyridines with broad functionalities have been synthesized regioselectively. This methodology is also applicable to imidazo[2,1-b]thiazole and benzo[d]imidazo[2,1-b]thiazole.
Agid:
5505103