Jump to Main Content
Photoredox-Catalyzed Ketyl–Olefin Coupling for the Synthesis of Substituted Chromanols
- Fava, Eleonora, Nakajima, Masaki, Nguyen, Anh L. P., Rueping, Magnus
- Journal of organic chemistry 2016 v.81 no.16 pp. 6959-6964
- aldehydes, alkenes, alkynes, catalysts, chemical structure, electron transfer, organic chemistry
- A visible light photoredox-catalyzed aldehyde olefin cyclization is reported. The method represents a formal hydroacylation of alkenes and alkynes and provides chromanol derivatives in good yields. The protocol takes advantage of the double role played by trialkylamines (NR₃) which act as (i) electron donors for reducing the catalyst and (ii) proton donors to activate the substrate via a proton-coupled electron transfer.