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Protective effect of hexahydrobenzo[c]phenanthridine alkaloids isolated from Corydalis ambigua var. amurensis on myocardial ischemia-hypoxia cells

Author:
Liu, Zhi-Hui, Li, Qiao, Chang, Sheng, Yang, Zhi-You, Han, Na, Yin, Jun
Source:
Phytochemistry letters 2016 v.17 pp. 258-262
ISSN:
1874-3900
Subject:
Corydalis, active ingredients, alkaloids, cell viability, leaves, myocardium, protective effect, spectral analysis
Abstract:
Two new hexahydrobenzo[c] phenanthridine alkaloids, ambiguanine H (1) and ambiguanine I (2) together with six known hexahydrobenzo[c] phenanthridine alkaloids (3⿿8), were isolated and purified from the Corydais ambigua var. amurensis leaves. Their structures were elucidated by extensive spectroscopic methods and all the compounds except comp. 6 showed the remarkable protective effect on myocardium ischemia-hypoxia cells and comp. 4 was the most active compound with cell viability of 49.4, 53.3, 68.2 and 84.5% in the range of at 0.01⿿10μmol/L which were stronger than that of salvia acid B.
Agid:
5507711