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Stability and Bioavailability of Lentztrehaloses A, B, and C as Replacements for Trehalose

Author:
Wada, Shun-ichi, Sawa, Ryuichi, Ohba, Shun-ichi, Hayashi, Chigusa, Umekita, Maya, Shibuya, Yuko, lijima, Kiyoko, Iwanami, Fumiki, Igarashi, Masayuki
Source:
Journal of agricultural and food chemistry 2016 v.64 no.38 pp. 7121-7126
ISSN:
0021-8561
Subject:
bioavailability, blood, cell culture, digestion, drugs, feces, mice, microorganisms, neoplasms, oral administration, pharmacokinetics, trehalase, trehalose, urine
Abstract:
Trehalose is widely used as a sweetener, humectant, and stabilizer, but is ubiquitously degraded by the enzyme trehalase expressed in a broad variety of organisms. The stability of the new trehalose analogues lentztrehaloses A, B, and C in microbial and mammalian cell cultures and their pharmacokinetics in mice were analyzed to evaluate their potential as successors of trehalose. Among the 12 species of microbes and 2 cancer cell lines tested, 7 digested trehalose, whereas no definitive digestion of the lentztrehaloses was observed in any of them. When orally administered to mice (0.5 g/kg), trehalose was not clearly detected in blood and urine and only slightly detected in feces. However, lentztrehaloses were detected in blood at >1 μg/mL over several hours and were eventually excreted in feces and urine. These results indicate that lentztrehaloses may potentially replace trehalose as nonperishable materials and drug candidates with better bioavailabilities.
Agid:
5510020