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Silver-mediated C–H bond functionalization: one-pot to construct substituted indolizines from 2-alkylazaarenes with alkynes

Author:
Tan, Xian-chun, Liang, Ying, Bao, Fang-ping, Wang, Heng-shan, Pan, Ying-ming
Source:
Tetrahedron 2014 v.70 pp. 6717-6722
ISSN:
0040-4020
Subject:
alkynes, chemical bonding, chemical reactions, chemical structure
Abstract:
A new silver-mediated highly selective C–H functionalization of 2-alkylazaarenes with internal and terminal alkynes for the creation of substituted indolizines in one-pot has been demonstrated. This process firstly represents a simple, efficient, and atom-economic way to construct polysubstituted indolizines in good yields from internal and terminal alkynes through C–H functionalization of 2-alkylazaarenes.
Agid:
5514141