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NiCl2-catalyzed cascade reaction of isocyanides with functionalized anilines
- Wang, Gao-Nan, Zhu, Tong-Hao, Wang, Shun-Yi, Wei, Tian-Qi, Ji, Shun-Jun
- Tetrahedron 2014 v.70 pp. 8079-8083
- chemical reactions, chemical structure, organic compounds, oxidants
- A NiCl2-catalyzed isocyanide insertion reaction of anilines bearing another nucleophile functional group utilizing TEMPO as oxidant in isopropyl ethanoate (IPA) or THF has been reported. This simple and general method could afford 2-aminobenzimidazole, 2-aminobenzothiazole, 2-aminobenzoxazole, as well as 2-aminobenzo[d][1,3]oxazine in moderate to excellent yields (up to 95% yield).