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NiCl2-catalyzed cascade reaction of isocyanides with functionalized anilines

Author:
Wang, Gao-Nan, Zhu, Tong-Hao, Wang, Shun-Yi, Wei, Tian-Qi, Ji, Shun-Jun
Source:
Tetrahedron 2014 v.70 pp. 8079-8083
ISSN:
0040-4020
Subject:
chemical reactions, chemical structure, organic compounds, oxidants
Abstract:
A NiCl2-catalyzed isocyanide insertion reaction of anilines bearing another nucleophile functional group utilizing TEMPO as oxidant in isopropyl ethanoate (IPA) or THF has been reported. This simple and general method could afford 2-aminobenzimidazole, 2-aminobenzothiazole, 2-aminobenzoxazole, as well as 2-aminobenzo[d][1,3]oxazine in moderate to excellent yields (up to 95% yield).
Agid:
5514191