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Reductive removal of methoxyacetyl protective group using sodium borohydride

Author:
Gadekar, Pradip K., Hoermann, Maryann, Corbo, Faith, Sharma, Rajiv, Sarveswari, S., Roychowdhury, Abhijit
Source:
Tetrahedron letters 2014 v.55 pp. 503-506
ISSN:
0040-4039
Subject:
alcohols, chemical reactions, chemical structure, sodium
Abstract:
Herein, we have developed a mild and selective reductive deprotection method for the MAc protected alcohols using sodium borohydride. The new deprotection conditions provide a complete orthogonality between O-MAc and other protecting groups such as tert-butyl ester, N-Boc, Fmoc, Cbz, O-TBDMS, N-benzyl, O-benzyl, O-acetyl, N-acetyl, N-MAc, etc. In addition to O-MAc deprotection, this method is also applicable for S-MAc deprotection.
Agid:
5515861