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Microexons Go Big
- Yang, Li, Chen, Ling-Ling
- Cell 2014 v.159 pp. 1488-1489
- RNA-binding proteins, alternative splicing, autism, genome, neurogenesis, transcriptome
- Microexons are frequently underestimated in transcriptome analyses. Two studies published in Cell and Genome Research now independently report the identification of hundreds of microexons. Alternative splicing of some microexons is regulated by neuronal-specific RNA-binding proteins and modifies the function of proteins involved in neurogenesis, with misregulation linked to autism.