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Super-Enhancer Transcription Converges on AID
- Alinikula, Jukka, Schatz, David G.
- Cell 2014 v.159 pp. 1490-1492
- genes, regulatory sequences, transcription (genetics)
- AID mis-targeting is poorly understood but contributes significantly to B cell genome instability. Two new papers in Cell reveal that AID mistargeting occurs primarily in gene bodies within a nuclear microenvironment characterized by high levels of transcriptional activity, interconnected transcriptional regulatory elements, and overlapping sense and antisense (convergent) transcription.