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A Happy 3′ Ending to the piRNA Maturation Story
- Czech, Benjamin, Hannon, Gregory J.
- Cell 2016 v.164 pp. 838-840
- RNA, biogenesis, proteins, silkworms
- For a decade, mystery has surrounded the mechanisms by which piRNA biogenesis yields distinct size classes of small RNAs within individual PIWI proteins. In this issue of Cell, two studies shed light on this process, identifying conserved PARN-family exonucleases that trim piRNAs to their mature size in silkworms and C. elegans.