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A Time Bomb for Leukemia
- Maryanovich, Maria, Frenette, Paul S.
- Cell 2016 v.165 pp. 262-263
- carcinogenesis, circadian rhythm, leukemia, stem cells, transcription factors
- Alterations of the circadian clock have been linked to cancer development. Puram et al. (in this issue) now uncover differential requirements between healthy hematopoietic and diseased leukemic stem cells for core circadian transcription factors, wherein leukemic cells depend on the clock machinery for survival and growth.