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Anti-cancer, pharmacokinetics and tumor localization studies of pH-, RF- and thermo-responsive nanoparticles
- Sanoj Rejinold, N., Thomas, Reju George, Muthiah, Muthunarayanan, Chennazhi, K.P., Manzoor, K., Park, In-Kyu, Jeong, Yong Yeon, Jayakumar, R.
- International journal of biological macromolecules 2015 v.74 pp. 249-262
- apoptosis, colorectal neoplasms, crosslinking, curcumin, energy, heat, mice, nanogold, nanomedicine, nanoparticles, neoplasm cells, pH, pharmacokinetics, temperature
- The curcumin-encapsulated chitosan-graft-poly(N-vinyl caprolactam) nanoparticles containing gold nanoparticles (Au-CRC-TRC-NPs) were developed by ionic cross-linking method. After “optimum RF exposure” at 40W for 5min, Au-CRC-TRC-NPs dissipated heat energy in the range of ∼42°C, the lower critical solution temperature (LCST) of chitosan-graft-poly(N-vinyl caprolactam), causing controlled curcumin release and apoptosis to cancer cells. Further, in vivo PK/PD studies on swiss albino mice revealed that Au-CRC-TRC-NPs could be sustained in circulation for a week with no harm to internal organs. The colon tumor localization studies revealed that Au-CRC-TRC-NPs were retained in tumor for a week. These results throw light on their feasibility as multi-responsive nanomedicine for RF-assisted cancer treatment modalities.