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Carboxylated graphene oxide functionalized with β-cyclodextrin—Engineering of a novel nanohybrid drug carrier

Author:
Meng, Na, Su, YuTian, Zhou, Ninglin, Zhang, Ming, Shao, Maoni, Fan, Yunting, Zhu, Haomiao, Yuan, Ping, Chi, Cheng, Xiao, Yinghong
Source:
International journal of biological macromolecules 2016 v.93 pp. 117-122
ISSN:
0141-8130
Subject:
Fourier transform infrared spectroscopy, X-ray diffraction, cyclodextrins, dispersibility, drug carriers, esterification, graphene oxide, hydrogen bonding, medicine, scanning electron microscopy, solubility, thermogravimetry, transmission electron microscopy
Abstract:
In this paper, we selected biocompatible carboxylated graphene oxide (GeneO-COOH) as a base material. The nanohybrid drug carriers composed of GeneO-COOH and cyclodextrin (β-CD), have been successfully synthesized through esterification and self-assembly technique. The nanohybrid drug carriers of GeneO-COO-β-CD were characterized by X-ray diffraction (XRD), fourier infrared spectroscopy (FTIR), thermogravimetric analysis (TG), scanning electron microscopy (SEM), transmission electron microscopy (TEM) and solubility experiments. Results indicated that the nanohybrid was obtained with GeneO-COOH forming the core and a large number of β-CD molecules forming the shell with a special structure. In the nanohybrid, the westerification between GeneO-COOH and β-CD led to the formation of covalent bonds, while adjacent β-CD molecules engineer an outer shell composed of 100 β-CD molecules (ca. 800nm of thickness) in the form of a layer-by-layer self-assembly due to hydrogen-bonding interaction. The obtained novel nanohybrid drug carriers of GeneO-COO-β-CD possessed good dispersibility in water media and the solutions were found to remain stable for 12 months,providing a possibility for further applications in biology, medicine, agriculture and other fields.
Agid:
5519529