Main content area

Carboxylated graphene oxide functionalized with β-cyclodextrin—Engineering of a novel nanohybrid drug carrier

Meng, Na, Su, YuTian, Zhou, Ninglin, Zhang, Ming, Shao, Maoni, Fan, Yunting, Zhu, Haomiao, Yuan, Ping, Chi, Cheng, Xiao, Yinghong
International journal of biological macromolecules 2016 v.93 pp. 117-122
Fourier transform infrared spectroscopy, X-ray diffraction, cyclodextrins, dispersibility, drug carriers, esterification, graphene oxide, hydrogen bonding, medicine, scanning electron microscopy, solubility, thermogravimetry, transmission electron microscopy
In this paper, we selected biocompatible carboxylated graphene oxide (GeneO-COOH) as a base material. The nanohybrid drug carriers composed of GeneO-COOH and cyclodextrin (β-CD), have been successfully synthesized through esterification and self-assembly technique. The nanohybrid drug carriers of GeneO-COO-β-CD were characterized by X-ray diffraction (XRD), fourier infrared spectroscopy (FTIR), thermogravimetric analysis (TG), scanning electron microscopy (SEM), transmission electron microscopy (TEM) and solubility experiments. Results indicated that the nanohybrid was obtained with GeneO-COOH forming the core and a large number of β-CD molecules forming the shell with a special structure. In the nanohybrid, the westerification between GeneO-COOH and β-CD led to the formation of covalent bonds, while adjacent β-CD molecules engineer an outer shell composed of 100 β-CD molecules (ca. 800nm of thickness) in the form of a layer-by-layer self-assembly due to hydrogen-bonding interaction. The obtained novel nanohybrid drug carriers of GeneO-COO-β-CD possessed good dispersibility in water media and the solutions were found to remain stable for 12 months,providing a possibility for further applications in biology, medicine, agriculture and other fields.