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Photosynthetic production of itaconic acid in Synechocystis sp. PCC6803
- Chin, Taejun, Sano, Mei, Takahashi, Tetsuya, Ohara, Hitomi, Aso, Yuji
- Journal of biotechnology 2015 v.195 pp. 43-45
- Synechocystis, air, biosynthesis, carbon dioxide, photosynthesis
- Here, we report the photosynthetic production of itaconic acid (IA), a promising building block, from carbon dioxide (CO2) by Synechocystis sp. PCC6803. The engineered PCC6803 strain expressing cis-aconitate decarboxylase, the key enzyme in IA biosynthesis, produced 0.9mg/L and 14.5mg/L of IA at production rates of 42.8μgL−1day−1 and 919.0μgL−1day−1, under conditions of constant bubbling with air and 5% CO2, respectively. This is the first report on the possibility of IA production from CO2 via the photosynthetic process in cyanobacteria.