PubAg

Main content area

Chromatin and epigenetic determinants of estrogen receptor alpha (ESR1) signaling

Author:
Magnani, Luca, Lupien, Mathieu
Source:
Molecular and Cellular Endocrinology 2014 v.382 pp. 633-641
ISSN:
0303-7207
Subject:
DNA, breast neoplasms, chromatin, epigenetics, estrogen receptors, growth factors
Abstract:
The oestrogen receptor alpha (ESR1) is a transcription factor that potentiates the response to diverse stimuli, including oestrogen and growth factors, in various tissue types. Its recruitment to the DNA is directly regulated by the chromatin landscape, inclusive of chromatin compaction and epigenetic modifications. In this review we discuss our current understanding of the interplay between ESR1 signaling and the chromatin landscape. We present how the chromatin landscape primes the lineage-specific response and contributes to stimuli-specific signaling. Finally, we discuss recent efforts to decipher the relationship between genetic and epigenetic as it relates to ESR1 signaling in breast cancer.
Agid:
5522457