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Distinctions between transgenerational and non-transgenerational epimutations

Author:
McCarrey, John R.
Source:
Molecular and Cellular Endocrinology 2014 v.398 pp. 13-23
ISSN:
0303-7207
Subject:
epigenetics, inheritance (genetics), mammals, mutation, transgenesis
Abstract:
Recent studies have described numerous environmentally-induced disruptions of the epigenome (epimutations) in mammals. While some of these appear to be corrected by normal germline-specific epigenetic reprogramming and are therefore not transmitted transgenerationally, others are not corrected and are transmitted over multiple subsequent generations. The mechanism(s) that distinguish transgenerational and non-transgenerational epimutations have not been delineated. This review examines several potential molecular and developmental distinctions between transgenerational and non-transgenerational epimutations in the context of the likelihood that any of these may or may not contribute to transgenerational inheritance of epimutations.
Agid:
5522705