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MicroRNA signatures highlight new breast cancer subtypes
- Bhattacharyya, Malay, Nath, Joyshree, Bandyopadhyay, Sanghamitra
- Gene 2015 v.556 pp. 192-198
- breast neoplasms, carcinogenesis, messenger RNA, microRNA, non-coding RNA, nucleotides
- MicroRNAs (miRNAs) are a kind of short non-coding RNAs, of about 22 nucleotides in length, which modulate and sometimes degrade the target mRNAs thereby regulating a number of cellular functions. Recent research in this area establishes the involvement of miRNAs in various disease progressions, including certain types of cancer development. Further, genome-wide expression profiling of miRNAs has been proven to be useful for differentiating various cancer types. In this paper, we have used miRNA expression profiles over a large set of breast cancer tumor samples for identifying subtypes of breast cancers. The experimental results demonstrate that miRNAs carry a unique signature that distinguishes cancer subtypes and reveal new cancer subtypes. Additional survival analyses based on clinical data also strengthen this claim.