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Association of common eNOS/NOS3 polymorphisms with preeclampsia in Tunisian Arabs

Ben Ali Gannoun, Marwa, Zitouni, Hedia, Raguema, Nozha, Maleh, Wided, Gris, Jean-Christophe, Almawi, Wassim, Mahjoub, Touhami
Gene 2015 v.569 pp. 303-307
Arabs, alleles, case-control studies, endothelial nitric oxide synthase, genetic variation, heterozygosity, homozygosity, loci, patients, pre-eclampsia, regression analysis, risk factors, women
We investigated the association of endothelial nitric oxide synthase (NOS3) polymorphisms −786T>C, 27-bp repeat 4b/4a, and Glu298Asp with preeclampsia (PE). This was a case–control study involving 345 unrelated Tunisian women with PE and 289 unrelated age- and ethnically matched control women. The −786C allele was significantly increased in PA patients when compared to healthy controls (P=0.015). In contrast, MAF of Glu298Asp (P=0.103) and 4b/4a (P=0.168) were not significantly different between the study groups. Higher frequencies of heterozygous Glu298/298Asp and homozygous −786T/−786T genotypes were seen in PE cases compared to healthy subjects. The combination of genotypes 221 (−786T>C, Glu298Asp, 4a/4a) was more in PE cases compared with control women (17.68% vs. 8.36%; P=0.029). Multivariate regression analysis confirmed this association. Genetic variation at the NOS3 locus represents a genetic risk factor for increased susceptibility to PE.